Nicole Stott is a veteran of 2 spaceflights and 104 days living and working in space on both the Space Shuttle and the International Space Station (ISS). Highlights of her spaceflight missions include 3 Space Shuttle flights (STS128, STS129, STS133), 2 ISS Expeditions (20 & 21), 1 spacewalk (10th woman), flying the robotic arm for the first track and capture of the free flying Japanese HTV cargo vehicle, a wide variety of science and research activities, installation and first run on the C.O.L.B.E.R.T. treadmill, and ISS maintenance.  She was the last ISS crewmember to return to Earth on a Space Shuttle.

Nicole's 28 year NASA career started at the Kennedy Space Center (KSC) in Florida where she worked as an engineer and manager for the Space Shuttle and ISS programs. Nicole gained valuable hands-on, operational experience with the actual spaceflight hardware and worked alongside the team of people responsible for the "care and feeding" of the vehicles.

Prior to being selected as an Astronaut, Nicole worked for 2 years at the Johnson Space Center (JSC) in Houston as a Flight Simulation Engineer (FSE) in the NASA Aircraft Operations Division.  As an FSE she flew as a crewmember onboard the Shuttle Training Aircraft (STA) helping to train astronaut pilots to fly the Space Shuttle. She also flew a range of other missions in the NASA T38's and the KC135 ("Vomit Comet").

Nicole was selected as an Astronaut in 2000 ~ one of 17 members of the 18th group of NASA Astronauts, call sign "The Bugs".